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butabarbital will lower the extent or impact of nifedipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.butabarbital will lessen the level or impact of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Regardless if you are picking out physical game